Endocrine Abstracts

Introduction: Some recent data indicates that high levels of homocysteine (Hcy) can be independent risk factor for osteoporosis and fractures in elderly. There are few explanations how homocysteine influence bone resorption and probably modify effect of therapy for osteoporosis. 1. Hcy interferes with collagen cross-linking. 2. High levels of Hcy specially stimulate resorptive activity of osteoclasts in vitro. 3. Hcy interfere bisphosphonates binding to hydroxyapatite.<...